John Libbey Eurotext

European Journal of Dermatology

Mixed connective tissue disease with bilateral erythematous palpebral oedema and targetoid skin lesions Volume 27, issue 1, January-February 2017

Figures

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Authors
1 Division of Dermatology, Tohoku Medical and Pharmaceutical University, 1-12-1 Fukumuro, Miyagino-ku, Sendai 983-8512,
2 Division of Hematology and Rheumatology, Tohoku Medical and Pharmaceutical University, 1-12-1 Fukumuro, Miyagino-ku, Sendai 983-8512,
3 Division of Clinical Pathology, Tohoku Medical and Pharmaceutical University, 1-12-1 Fukumuro, Miyagino-ku, Sendai 983-8512, Japan

Mixed connective tissue disease (MCTD) is a rare connective tissue disease with an autoimmune background. Clinically, it is characterised by manifestations shared with other connective tissue diseases; systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and polymyositis/dermatomyositis [1, 2]. High titres of distinct serum autoantibodies to the U1 small nuclear ribonucleoprotein (RNP) are characteristic of MCTD. Several skin manifestations of MCTD are known, including Raynaud's phenomenon, [...]