John Libbey Eurotext

European Journal of Dermatology

MicroRNA in skin diseases Volume 27, issue 4, July-August 2017

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Authors
Department of Pathophysiology,
Krasnoyarsk State Medical University,
P. Zeleznyaka str. 1, 660022, Krasnoyarsk,
Russian Federation
* Reprints
  • Key words: atopic dermatitis, lichen planus, microRNA, psoriasis, skin disease, vitiligo
  • DOI : 10.1684/ejd.2017.3024
  • Page(s) : 343-52
  • Published in: 2017

MicroRNAs are essential regulators of various cellular processes such as cell growth, differentiation, apoptosis, and the immune response, acting as factors for translational repression and/or degradation of target messenger RNA. Currently, microRNAs are considered as promising biomarkers and therapeutic targets for different pathological conditions. Skin may serve as a convenient model for microRNA modulation studies due to the comparatively easy access to targets cells. Cutaneous diseases are characterized by multiple intercellular communication pathways, triggered by diverse stimuli and mediated by heterogenous regulators, including microRNAs. The goal of this article is to summarize the state of research in dermatology concerning the action of microRNAs as epigenetic modulators.