John Libbey Eurotext

European Journal of Dermatology

Maculopapular rash during a nadir period in a patient with acute myeloid leukaemia Volume 27, issue 3, May-June 2017

Figures

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Authors
1 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
2 Institute for Advancement of Clinical and Translational Science, Kyoto University Hospital, Kyoto, Japan
3 Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan
4 Department of Hematology and Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan
5 Department of Hematology and Immunology, Kanazawa Medical University, Ishikawa, Japan

Maculopapular rash (MPR) is caused by T cell-mediated hypersensitivity to infection or drugs [1]. The skin infiltrate consists largely of CD4+ and CD8+ T cells in the upper dermis. Little is known about the origin of these pathogenic T cells. Here, we report a case of MPR that occurred during a nadir period in a patient with acute myeloid leukaemia (AML) treated by chemotherapy. Despite the severe reduction of circulating leukocytes, T cells remained in the affected skin. Our case suggests the capability [...]