JLE

European Journal of Dermatology

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Lysine acetylsalicylate decreases proliferation and extracellular matrix gene expression rate in keloid fibroblasts in vitro Volume 12, issue 3, May - June 2002

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Department of Dermatology, Universität Leipzig, Liebigstraße 21, D-04103 Leipzig, Germany.

Background: In genetically predisposed individuals keloids are formed as benign collagenous tumors. Objective: The purpose of this study was to investigate whether the proliferation and matrix gene expression of keloid fibroblasts is differently influenced by the anti-inflammatory active drug lysine acetylsalicylate (LAS) when compared to normal skin fibroblasts in vitro. Methods: Normal skin and keloid fibroblasts derived from human donors were compared. Results: Excessive scarring and the formation of keloids are (at least in part) due to an overproduction of collagen types I and III. The results show a significant dose-dependent anti-proliferative effect of lysine acetylsalicylate. At the level of gene expression we observed a pronounced inhibitory effect of LAS on procollagen I and III mRNA synthesis, whereas matrix metalloproteinase 1 and tissue inhibitor of metalloproteinases 1 were not altered. Conclusions: Further clinical studies are planned to evaluate these effects of a high-dose treatment of keloids with LAS.