Figures
Figure 1
A ) Multiple, ill-defined, confluent, brown macules with varying size on the abdomen during the resting phase. These lesions were refractory to both a patch test and an oral challenge test (OCT) with acetaminophen. B )Development of erythematous macules (red arrows) around the brown macules (black arrows) on the left thigh, two hours after OCT with acetaminophen. C ) Histopathology of a brown macule on the abdomen in the resting stage showing increased pigmentation of the basal layer and pigment incontinence. (D ) A brown macule on the thigh in the resting stage displaying increased pigmentation of the basal layer and pigmentary incontinence. (E ) An erythematous macule on the thigh, 12 hours after OCT, displaying hydropic degeneration of the basal layer, dyskeratotic keratinocytes, and perivascular infiltration of lymphocytes in the dermis (hematoxylin-eosin; original magnification: ×200). F , G ) Change in the distribution of CD3+, CD4+, CD8+, and Foxp3+ cells, which correspond to regulatory T cells (Tregs), in the lesional epidermis (F ) and dermis (G ) on the abdomen or thigh in the resting stage, and 12 hours after OCT on the thigh. Numbers of CD3+, CD4+, CD8+ and Foxp3+ cells/mm epidermal length and mm2 dermis were counted. The data represent mean ± SEM of measurements obtained from four sections from a single sample. Statistical comparison between groups was performed using the Student's t-test. Statistical significance was set at *p <0.05 and ***p <0.01.
Figure 1
Authors
1 Department of Dermatology, Okayama City Hospital, Okayama, Japan
2 Department of Dermatology, Kawasaki Medical Center, Kawasaki Medical School, Okayama, Japan
3 Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan
4 Department of Dermatology, Okamuraisshindo Hospital, Okayama, Japan
Fixed drug eruption (FDE) usually relapses at the same sites with each administration of the causative drug [1, 2]. However, there is a deviation from this characteristic sequence; certain sites are not involved with subsequent flare, while other sites are flared, creating a “wandering” appearance [3, 4]. Accumulating evidence indicates that FDE occurs following activation of skin-resident memory T cells (TRM) [1] and its amelioration is associated with the influx of regulatory T cells (Tregs) [5]. [...]