European Journal of Dermatology
MENUInterest of PS100 assay when 99mTc sestamibi scintigraphy failed to identify lymph node metastases of melanoma Volume 11, issue 5, September - October 2001
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- Key words: protein S-100, 99mTc MIBI, malignant melanoma, lymph node, metastases, chemoresistance
- Page(s) : 432-5
- Published in: 2001
The study evaluated the contribution of serum PS100 assay to the detection of lymph node metastases during the follow-up of patients previously treated for a malignant melanoma, in addition to 99mTc sestamibi (MIBI) scintigraphy and investigation for gene MDR1, in order to detect chemoresistance phenomena. The study included 37 patients with a clinically questionable lymph node around basin lymphatic areas of the previously surgically-treated malignant melanoma. The sensitivity and specificity of PS100 assay were 91% and 86.5%, respectively. The sensitivity and specificity of MIBI scintigraphy were 95% and 85%, respectively. Overexpression of gene MDR1 was observed in six cases. In the event of negative scintigraphic findings, the concomitant analysis of PS100 levels and the scintigraphic result enabled the metastatic MDR+ patients to be distinguished from the non-metastatic patients. PS100 assay may therefore be proposed for the follow-up of malignant melanoma.