Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland
Department of Clinical Microbiology, University of Eastern Finland, 70210 Kuopio, Finland
- Key words: mast cell, vitamin D, skin, cancer, psoriasis
- DOI : 10.1684/ejd.2017.3132
- Page(s) : 590-8
- Published in: 2017
In mouse skin models, mast cells have been shown to express vitamin D receptor (VDR) that can mediate the immunosuppressive effects of ultraviolet B radiation and vitamin D3. However, VDR activation leads to the expression of CYP24A1, a hydroxylase that can inactivate vitamin D3 metabolites.