John Libbey Eurotext

European Journal of Dermatology

Immunoreactivity to CYP24A1, but not vitamin D receptor, is increased in mast cells of keratinocyte skin cancers Volume 27, issue 6, November-December 2017

Figures

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Tables

Authors
1 Department of Dermatology, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland
2 Department of Clinical Microbiology, University of Eastern Finland, 70210 Kuopio, Finland
* Reprints
  • Key words: mast cell, vitamin D, skin, cancer, psoriasis
  • DOI : 10.1684/ejd.2017.3132
  • Page(s) : 590-8
  • Published in: 2017

Background

In mouse skin models, mast cells have been shown to express vitamin D receptor (VDR) that can mediate the immunosuppressive effects of ultraviolet B radiation and vitamin D3. However, VDR activation leads to the expression of CYP24A1, a hydroxylase that can inactivate vitamin D3 metabolites.