John Libbey Eurotext

European Journal of Dermatology


Illustration of diagnostic and prognostic difficulties during the early stages of generalized bullous fixed drug eruptions Volume 27, issue 1, January-February 2017


  • Figure 1
Service de Dermatologie-Vénérologie, Hôpital Jean Bernard, Centre Hospitalier de Valenciennes, Avenue Désandrouin, 59 322 Valenciennes, France

Bullous drug eruptions are infrequent and potentially serious situations. Bullae are characteristic of two main diagnoses: the spectre of toxic epidermal necrolysis (TEN), the most serious, and the bullous fixed drug eruption (FDE); even if other severe drug reactions can sometimes be bullous. The FDE exceptionally occurs as a bullous and generalized form in western countries [1, 2]. Early recognition is necessary because of a potential emergency situation. The distinction between these two entities [...]