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European Journal of Dermatology

Human papillomavirus 13 in a Mexican Mayan community with multifocal epithelial hyperplasia: could saliva be involved in household transmission? Volume 21, issue 3, May-June 2011

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Authors
Dentistry School, University of Yucatan, Merida Yucatan, México, Virology Laboratory, University of Yucatan, Avenida Itzaez y calle 59 No.490 Centro, CP 97000, Merida Yucatan, México, Dermatology Center, Health Ministry, Merida Yucatan
  • Key words: human papillomavirus, Mexico, Mayan, multifocal epithelial hyperplasia, type 13
  • DOI : 10.1684/ejd.2011.1347
  • Page(s) : 396-400
  • Published in: 2011

Multifocal epithelial hyperplasia (MEH) is a disease of the oral mucosa. Human papillomaviruses 13 and 32 have been detected in these lesions. We describe the epidemiology and clinical characteristics of patients with MEH in a rural community in the Mayan area of Mexico with 53 cases and 54 controls. Clinical and epidemiological data were collected through a direct interview. Oral cell samples were collected with a cytobrush. Subjects collected their own saliva sample in a sterile bottle. All samples were tested for HPV 13 and 32 by polymerase chain reaction using specific primers. Of the 53 patients and 54 healthy subjects, 56% were < 12 years old, 25% were males and 75% females. Evolution of the lesions was between two months and 17 years. The lesions affected lips, jugal mucosa, and tongue, 96% had multiple lesions. From 53 patients, fifty samples of oral cells and 31samples of saliva were analyzed. HPV 13 was detected in 100% oral cell and 100% saliva samples studied. 16 healthy subjects were HVP 13 positive. A highly significant association of HPV 13 infection and MEH was found, as determined by chi square test (p = 0.00) Household transmission of HPV 13 may happen through saliva and the shared use of contaminated objects.