- Author(s): M. Hirose, T. Akiyama, Y. Ichiki, S. Satoh, T. Izumi, M. Seishima, Y. Kitajima
, Department of Dermatology, Gifu University School of Medicine, Tsukasamachi 40, Gifu, Japan.
- Key words: abortion, bullous disease, bullous pemphigoid antigen, herpes gestationis, immunoblot, immunofluorescence study.
- Page(s) : 134-6
- Published in: 2000
A 32-year old patient developed herpes gestationis (HG) characterized by edematous and erythematous plaques with bullae on the breast and abdomen in the sixth week of her third pregnancy. Direct immunofluorescence study showed a linear deposition of C3 at the basement membrane zone of the skin lesions. Although indirect immunofluorescence study showed IgG-positive staining at the basement membrane zone, HG factor was negative. Immunoblotting against epidermal extract revealed the presence of IgG antibody directed to 180 kDa protein, which was defined as the 180 kDa bullous pemphigoid antigen, in her serum. The skin lesions improved rapidly within 2 weeks after the abortion, while oral administration of prednisolone at the dose of 20 mg/day was not effective. Indirect immunofluorescence and immunoblot was positive at least for 2 months after the abortion without blister formation.