John Libbey Eurotext

European Journal of Dermatology

Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts Volume 19, issue 2, March-April 2009


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Institute of Natural Products for Health Promotion and Department of Preventive Medicine, College of Medicine, Kosin University, 34 Amnam-dong, Suh-gu, Busan, 602-702 Republic of Korea, Department of Laboratory Medicine, College of Medicine, Yonsei University; Seoul, 120-749, Korea, Pacific Institute of Bioorganic Chemistry of Far East Branch of the Russian Academy of Sciences; Vladivostok -22, Russia
  • Key words: fucoidan, matrix metalloproteinases-1, photoaging, type I procollagen, ultraviolet B, promoter activity
  • DOI : 10.1684/ejd.2008.0611
  • Page(s) : 129-34
  • Published in: 2009

UVB reduces type I procollagen levels and increases matrix metalloproteinases-1 (MMP-1) levels in human skin and plays a major role in the process of photoaging. We previously reported that fucoidan inhibits UVB-induced MMP-1 expression at the protein and mRNA levels in human skin fibroblasts (HS68). Yet, the effects of fucoidan on UVB-induced MMP-1 promoter activity and type I procollagen have not been investigated. In this study, we assessed the effects of fucoidan on the inhibition of MMP-1 promoter activity and on the increase of type I procollagen synthesis in human skin fibroblasts. Fucoidan treatment significantly inhibited MMP-1 promoter activity compared to UVB irradiation alone. Fucoidan treatment also increased type I procollagen mRNA and protein expression in a dose-dependent manner compared to the control. Our data indicate that fucoidan may prevent UVB-induced MMP-1 expression and inhibit down-regulation of type I procollagen synthesis. We suggest that fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.