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European Journal of Dermatology

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Expression of keratin 1, keratin 10, desmoglein 1 and desmocollin 1 in the epidermis: possible downregulation by interleukin-4 and interleukin-13 in atopic dermatitis Volume 27, issue 3, May-June 2017

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Authors
1 Department of Dermatology, Tokyo Women's Medical University, Tokyo, Japan
2 Department of Microbiology and Immunology, Tokyo Women's Medical University, Tokyo, Japan
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Background

In the pathogenesis of atopic dermatitis (AD), skin barrier dysfunction and T-helper (Th) type 2 immune reactions play important roles. Alterations in the stratum spinosum of AD have not been studied in much detail.