European Journal of Dermatology
MENUExpression of activation-induced cytidine deaminase in Merkel cell carcinoma with lymph-node metastasis Volume 23, issue 4, July-August 2013
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Department of Dermatology,
University of Occupational and Environmental Health,
1-1 Iseigaoka,
Yahatanishi-ku,
Kitakyushu 807-8555,
Japan
University of Occupational and Environmental Health,
1-1 Iseigaoka,
Yahatanishi-ku,
Kitakyushu 807-8555,
Japan
- DOI : 10.1684/ejd.2013.2078
- Page(s) : 539-40
- Published in: 2013
Merkel cell carcinoma (MCC) is an aggressive tumour of neuroendocrine origin. It has been shown that approximately 80% of MCC harbour a polyoma virus named Merkel cell polyoma virus (MCPyV).Activation-induced cytidine deaminase (AID), a member of the cytidine deaminase family, is essential for somatic hypermutation and class-switch recombination in immunoglobulin genes [1]. Recently, several lines of evidence have shown that inappropriately expressed AID induced by infections acts as a genomic mutator [...]