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European Journal of Dermatology

Erythroderma in the era of biological therapies Volume 22, issue 2, March-April 2012

Authors
Dermatology Unit, University of Padua, Via C. Battisti 206, 35128, Padova, Italy
  • Key words: anti-tumour necrosis factor-alpha, biological therapies, cutaneous lymphoma, erythroderma, psoriasis
  • DOI : 10.1684/ejd.2011.1569
  • Page(s) : 167-71
  • Published in: 2012

Erythroderma is a scaling erythematous dermatitis involving 90% or more of the cutaneous surface. Psoriasis and eczema are the most common dermatoses underlying erythroderma. Cutaneous T cell lymphomas can also cause erythroderma. Differential diagnosis between psoriatic erythroderma and lymphomatous erythroderma is often challenging. Tumour necrosis factor-alpha inhibitors are a new class of drugs used in the treatment of psoriasis, even in erythrodermic psoriasis. The effects of anti-tumour necrosis factor-alpha in cutaneous T cell lymphomas have not yet been established. Consequently, it is mandatory to treat an erythrodermic psoriatic patient with tumour necrosis factor-alpha blockers only if a lymphoproliferative cutaneous disorder has been excluded.