John Libbey Eurotext

European Journal of Dermatology


Eosin treatment for psoriasis reduces skin leukocyte infiltration and secretion of inflammatory chemokines and angiogenic factors Ahead of print


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1 Laboratory of Experimental Immunology,
2 Dermatology Division,
3 Rare Disease Centre, Istituto Dermopatico dell’Immacolata-IRCCS, via Monti di Creta 104, 00167 Rome, Italy
4 Dept. of Oncology and Molecular Medicine, Istituto Superiore di Sanità (ISS), viale Regina Elena 299, 00161 Rome, Italy
5 National Institute for Health, Migration and Poverty (NIHMP), via di S. Gallicano 25, 00153 Rome, Italy
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Psoriasis is a chronic inflammatory disease characterized by erythemato-squamous plaques with epidermal hyperplasia, increased vascularity, and a dermal mixed infiltrate of dendritic cells, T-lymphocytes, and natural killer cells [1]. Neutrophilic granulocytes are also key infiltrating cells in plaque psoriasis, where they are attracted by chemokines, growth-related oncogene α, and interleukin (IL)-8, released by activated keratinocytes and endothelial cells [2].The dialogue between psoriatic keratinocytes, [...]