John Libbey Eurotext

European Journal of Dermatology


Enhancement of mRNA expression of survivin and human beta-defensin-3 in lesions of psoriasis vulgaris Volume 26, issue 1, January-February 2016


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1 Department of Dermatology,
The First Affiliated Hospital,
Sun Yat-sen University,
Guangzhou, Guangdong,
2 Department of Dermatology,
Shekou People's Hospital, Shenzhen,
3 Department of Dermatology,
Huashan Hospital,
Fudan University,
No. 12 Wulumuqizhong Road,
Shanghai, 200040,
* Reprints
a Fang Wang and Xia Zhang contributed equally to this work.
  • Key words: human β-defensin-3, mRNA, psoriasis vulgaris, survivin
  • DOI : 10.1684/ejd.2015.2698
  • Page(s) : 28-33
  • Published in: 2016

Psoriasis vulgaris (PV) is a chronic inflammatory dermatosis, characterized by T helper cell 1 (Th1)/Th17/Th22-mediated inflammation, hyperproliferation and abnormal differentiation of epidermal keratinocytes, and angiogenesis [1, 2]. The proliferative cell population is approximately doubled in psoriasis, whereas the daily production of keratinocytes in psoriatic lesions is approximately 28 times greater than that in normal epidermis. However, the abnormal keratinocytes seem to strengthen the [...]