John Libbey Eurotext

European Journal of Dermatology


Effects of oral administration of Butyrivibrio fibrisolvens MDT-1 on the development and healing of atopic dermatitis in NC/Nga mice Volume 22, issue 2, March-April 2012


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Department of Life Science, Meiji University, Higashimita Tama-ku, Kawasaki 214-8571, Japan, Agricultural and Veterinary Research Laboratories, Meiji Seika Pharma Co., Ltd., Yokohama 222-8567, Japan, Animal Health Department, Meiji Seika Pharma Co., Ltd., Tokyo 104-8002, Japan
  • Key words: atopic dermatitis, Butyrivibrio fibrisolvens MDT-1, IgE, lipopolysaccharide
  • DOI : 10.1684/ejd.2011.1618
  • Page(s) : 211-7
  • Published in: 2012

The purpose of this study was to evaluate the effects of oral administration of Butyrivibrio fibrisolvens MDT-1 (MDT-1) on mite antigen-induced atopic dermatitis (AD) in NC/Nga mice. When administration of the freeze-dried cells of MDT-1 was initiated one week before mite-antigen swabbing, the development of AD-like skin lesions was alleviated. The cell homogenate and membrane fraction had similar effects, showing that cell components are effective. Freeze-dried cells were found to be replaceable by the crude lipopolysaccharide extracted from MDT-1. Alleviation of AD was concomitant with a decrease in the serum IgE level. Determination of cytokines produced by Peyer's patch cells showed that MDT-1 administration increased IL-12, tended to increase IFN-γ, and tended to decrease IL-10, but did not affect IL-4. When MDT-1 was administered after the skin lesions had progressed, the symptoms were ameliorated, suggesting that MDT-1 has AD-healing effects. MDT-1 was as effective as prednisolone, but different from prednisolone in that MDT-1 showed no detectable side effects such as body weight loss. We previously reported that MDT-1 administration prevented and alleviated colorectal cancer, sarcoma, and enterocolitis in mice. Taken together, MDT-1 might be beneficial for maintaining the health of pet animals and humans.