John Libbey Eurotext

European Journal of Dermatology

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DITRA syndrome in a Vietnamese patient: efficacy of etanercept Volume 28, issue 2, March-April 2018

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Authors
Dermatology department, University Hospital of Nancy, Vandoeuvre-les-Nancy, France

More than 80 cases of generalized pustular psoriasis (GPP) associated with a mutation of the interleukin-36 receptor antagonist (IL36RN) gene have been reported, and this syndrome is known as DITRA (deficiency of IL36RN). In patients with GPP and psoriasis vulgaris (PV), however, association with such mutation was not reported to be significant [1]. Fourteen different mutations of the IL36RN gene have been documented [2]; the c.115+6C>T mutation has only been described in Asian patients [3]. To date, [...]