Department of Dermatology. Kawasaki Medical School. Matshushima Str. 577, Kurashiki 701-0192, Japan.
- Key words: discoid lupus erythematosus, silica, superantigen, anti-nuclear factor, SLE.
- Page(s) : 127-30
- Published in: 2001
We observed a 26-year-old female patient with discoid lupus erythematosus on her left cheek skin, where fine fragments of windshield glass had been embedded in an automobile accident 8 years previously. She gradually developed general fatigue, morning stiffness of fingers and anti-nuclear antibody. As an etio-pathogenesis of this patient, we speculate that a long exposure to quartz (silica) could give rise to discoid lupus erythematosus in only local damaged areas and at the same time induce systemic immunological changes in some genetically restricted persons; such as production of anti-nuclear antibody. Silica has multi-potential biological effects, especially on immunological functions.