European Journal of Dermatology


Cutaneous and lingual papules as a sign of β2 microglobulin-derived amyloidosis in a long-term hemodialysis patient Volume 13, issue 4, July 2003


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Departments of Dermatology and Nephrology, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital, Hiroshima, Japan. Department of Dermatology, School of Medicine, Fukuoka University, Fukuoka, Japan. Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Although hemodialysis has permitted long-term survival of patients with renal failure, β2 microglobulin-derived amyloidosis is a serious complication occurring most commonly in long-term hemodialysis patients. Orthopedic manifestations are quite common, but cutaneous and lingual manifestations are relatively uncommon. We report a 56-year-old patient with lichenoid plaque type of skin eruptions and lingual papules caused by β2 microglobulin-derived amyloidosis. Immunohistochemical study showed that amyloid deposits were positive for anti-β2 microglobulin antibody, but negative for anti-advanced glycation end products antibody (anti-CML and CLE antibody). We discuss the histological and the clinical features of skin manifestations of β2 microglobulin-derived amyloidosis.