European Journal of Dermatology
MENUCutaneous and lingual papules as a sign of β2 microglobulin-derived amyloidosis in a long-term hemodialysis patient Volume 13, issue 4, July 2003
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- Key words: advanced glycation end products, cutaneous and lingual papules, β2 microglobulin-derived amyloidosis, lichenoid plaque type.
- Page(s) : 393-5
- Published in: 2003
Although hemodialysis has permitted long-term survival of patients with renal failure, β2 microglobulin-derived amyloidosis is a serious complication occurring most commonly in long-term hemodialysis patients. Orthopedic manifestations are quite common, but cutaneous and lingual manifestations are relatively uncommon. We report a 56-year-old patient with lichenoid plaque type of skin eruptions and lingual papules caused by β2 microglobulin-derived amyloidosis. Immunohistochemical study showed that amyloid deposits were positive for anti-β2 microglobulin antibody, but negative for anti-advanced glycation end products antibody (anti-CML and CLE antibody). We discuss the histological and the clinical features of skin manifestations of β2 microglobulin-derived amyloidosis.