CHU de Poitiers, 86021 Poitiers, France
Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC, Université de Poitiers, 86073 Poitiers, France
ImageUP, STIM, ERL 7368 Université de Poitiers, 86073 Poitiers, France
- Key words: cytokine, inflammation, psoriasis, biotherapy, adalimumab
- DOI : 10.1684/ejd.2017.3127
- Page(s) : 579-89
- Published in: 2017
In psoriasis, a specific cytokine network has been described to play a central role in the pathophysiology of the disease. Anti-cytokine therapeutic approaches have been largely developed and TNFα constitutes the main target. Adalimumab is a human anti-TNFα monoclonal antibody that has been reported to demonstrate clinical efficacy and safety, resulting in reversal of epidermal hyperplasia and cutaneous inflammation.