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European Journal of Dermatology

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Association between psoriasis and polymorphisms in the TNF, IL12B, and IL23R genes in Spanish patients Volume 23, issue 5, September-October 2013

Authors
Clinical Pharmacology Service,, Dermatology Service, Hospital Universitario de la Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria Princesa (IP), 28006 Madrid, Spain

Susceptibility to psoriasis has been associated with the HLA-C*0602 allele, although it may be affected by other polymorphisms.

We genotyped 142 patients and 160 healthy volunteers to evaluate the possible relationship between susceptibility to psoriasis and the HLA-C*0602 allele and polymorphisms in the TNF, IL12B, and IL23R genes.

The frequency of the wild-type TNF-238, TNF-308, and TNF-1031 genotypes was greater in patients with psoriasis than in healthy volunteers, although that of the mutant TNF-857 genotype was higher. The only difference between psoriasis and psoriatic arthritis was TNF-857. The frequency of the HLA-C*0602 allele was higher in psoriatic patients than in healthy volunteers. No differences were observed for IL12B and IL23R. Multivariate logistic regression analysis only confirmed these associations for TNF-238, TNF-857, and HLA-C*0602.

Our results support an association between susceptibility to psoriasis and TNF polymorphisms in the Spanish population.