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European Journal of Dermatology

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Association between Helicobacter pylori infection and vulvar lichen sclerosus: a clinical comparative study Volume 28, issue 2, March-April 2018

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Authors
1 Outpatient Department of Vulvar Diseases, Maternal and Children Department, Division of Obstetrics and Gynecology 2, Pisa University Hospital, Pisa, Italy
2 Department of Gynecologic-Obstetrical and Urologic Sciences, Sapienza University Hospital, Rome, Italy
3 Department of Gynecology, University of Rome “Campus Bio-Medico”, Rome, Italy
4 Biostatistics Unit, Regina Elena National Cancer Institute, Rome, Italy
5 Department of Oncology, IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy
6 Department of Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

Vulvar lichen sclerosus (VLS) is a chronic, inflammatory skin disease, affecting females in menopausal age. Estimated prevalence is one in 70 women [1], although this is probably underestimated [2]. Environmental factors have been suggested to act on genetically predisposed patients, triggering auto-immune mechanisms [1, 3]. Helicobacter pylori (HP) is a Gram-negative bacterium involved in the pathogenesis of chronic gastritis and gastric cancer [4, 5], but it might also exert systemic effects [...]