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An immunogenetic study of bullous pemphigoid with mucosal involvement in two siblings Volume 25, issue 2, April 2015

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Authors
1 Department of Dermatology,
Shinshu University School of Medicine,
3-1-1 Asahi, Matsumoto 390-8621, Japan
2 Division of Dermatology,
Matsumoto medical center,
Matsumoto 399-8701, Japan
3 Department of Dermatology,
Kurume University School of Medicine,
Fukuoka 830-0011, Japan

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease mostly affecting the elderly. Patients with BP usually have autoantibodies against BP180 and/or BP230, which are major components of hemidesmosomes. Although the etiology is unclear, many studies have shown that onset of BP is associated with human leukocyte antigen (HLA) [1]. Here, we report two sibling BP patients carrying the HLA-DQB1*03:01 and HLA-DRB1*04 alleles.Case 1: A 95-year-old Japanese man presented with a 1-month [...]