John Libbey Eurotext

European Journal of Dermatology


A follow-up report of acral melanoma in a patient with Nagashima-type palmoplantar keratosis: validation of SERPINB7 mutation and local recurrence Volume 28, issue 4, July-August 2018


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1 Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
2 Ijinkai Takeda General Hospital, Kyoto, Japan
3 Department of Dermatology, Keio University, Tokyo, Japan

We previously reported a patient with malignant melanoma (MM) occurring on Nagashima-type palmoplantar keratosis (NPPK), suggesting, for the first time, that NPPK can predispose to MM. In that report, NPPK was diagnosed on the basis of characteristic clinical manifestations and DNA sequencing to verify intact SLURP-1 (Secreted LY6/PLAUR Domain Containing 1), thereby excluding Meleda disease [1]. Recently, mutations in SERPINB7 (serine proteinase inhibitor B7) were shown to cause NPPK. We present [...]