Figures
Figure 1
A) A dome-shaped pigmented 16×12-mm nodule with a 5-mm ulceration on the lower right corner of the patient's right nasal wing. Black arrows and arrowheads indicate the nodule and the ulceration, respectively. B) Blue-white pseudo-network and diffuse hypopigmentation on the nodule, and a blue-grey structureless area and a pink-white structureless area at the edge of the ulceration. The dotted lines labelled as C and E indicate the sections of the histopathological specimen shown in (C ) and (E ), respectively. Black and white arrows indicate the blue-white pseudo-network and diffuse hypopigmentation, respectively. Black and white arrowheads indicate the blue-grey structureless area and the pink-white structureless area, respectively. C ) Melanocytic cells proliferated as nests in the dermis of the nodule and basaloid cells proliferated as nests at the ulceration. The dashed boxes labelled as D and G indicate areas shown in (D ) and (G ), respectively (hematoxylin and eosin stain [H&E]; original magnification: ×15). D ) Melanocytic cells proliferated as nests in the dermis (H&E; original magnification: ×100). E) Tumour nests with basaloid cells had spread and invaded the dermis at the ulceration. The dashed box labelled as F indicates the area shown in (F ) (H&E; original magnification: ×20). F) Melanin deposition was found in and around tumour nests with basaloid cells (H&E; original magnification: ×100). G) A tumour nest of basaloid cells was situated adjacent to melanocytic nevus cells (H&E; original magnification: ×100). H) Double immunostaining for Ber-EP4 (blue) in the BCC and S-100 (brown) in the melanocytic nevus. The dashed box labelled as I indicates the area shown in (I ) (original magnification: ×40), which corresponds approximately to the area depicted in (G ) at the interface between the BCC and melanocytic nevus (original magnification: ×200).
Figure 1
Authors
1 Department of Dermatology
2 Department of Plastic Surgery
3 Department of Pathology
Graduate School of Medical and Dental Sciences,
Tokyo Medical and Dental University,
1-5-45, Yushima, Bunkyo-ku,
Tokyo, 113-8510, Japan
4 Department of Dermatology,Tokyo Women's Medical University Medical Center East,
2-1-10, Nishi-Ogu, Arakawa-ku, Tokyo, 116-8567,
Japan
Basal cell carcinoma (BCC) and melanocytic nevus are derived from different origins of cells and the collision of these two tumours often confuses diagnosis [1-6]. To date, a detailed analysis, in terms of their locational association and histogenesis, has not been fully documented [7]. Here, we describe a case of BCC with a neighbouring melanocytic nevus on the nose. We elucidated how both lesions overlapped based on double-immunostaining for Ber-EP4 and S-100. In addition, we emphasize the critical [...]