John Libbey Eurotext

European Cytokine Network


Short-term effect of weight loss through restrictive bariatric surgery on serum levels of vaspin in morbidly obese subjects Volume 22, issue 4, December 2011

Department of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Tehran, Iran, Endocrine and Metabolism Research Center (EMRC), Obesity and Food group set, Tehran University of Medical Sciences, Tehran, Iran, Students'Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran, Department of Surgery, Laparoscopic Surgical Ward ,Sina hospital, Tehran University of Medical Sciences, Tehran, Iran, Epidemiology and Biostatistics Department, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  • Key words: obesity, weight reduction, laparoscopic adjustable gastric banding, laparoscopic total gastric vertical placation, visceral adipose tissue-derived serine protease inhibitor
  • DOI : 10.1684/ecn.2011.0295
  • Page(s) : 181-6
  • Published in: 2011

<p>The aims of this study were to evaluate the short-term effects of laparoscopic restrictive bariatric surgery (LRBS) on plasma levels of vaspin and the potential associations of changes in vaspin levels with changes in anthropometric indices, insulin-resistance and dietary intake.</p><p>Thirty, severely obese subjects (21 female; mean age, 32.5 years) with a mean body mass index (BMI) of 44.1 ± 4.9 kg/m 2 underwent LRBS. Measurements of anthropometric indices, dietary intakes, physical activity and plasma vaspin concentrations were performed prior to, and six weeks after LRBS. Insulin-sensitivity was estimated using the homeostasis model assessment of insulin-resistance (HOMA-IR).</p><p>Six weeks after LRBS, BMI decreased to a mean of 38.4 ± 4.9 kg/m 2. Significant reductions were also observed in waist circumference (WC), daily intakes of calorie, fat and protein, and plasma concentrations of triglyceride. No significant change was observed in fasting levels of insulin, blood sugar or HOMA-IR. Vaspin decreased significantly (0.26 ± 0.17 vs 0.36 ± 0.20, p=0.048) following surgery. While the percentage change of vaspin was not correlated with percent changes in anthropometric indices and HOMA-IR, it correlated positively with the percentage change in intake of calories, fat and protein: this correlation remained significant even after adjustment for sex and changes in WC and HOMA-IR.</p><p>Our study suggests that LRBS decreases the serum vaspin concentrations in parallel with the restriction of dietary intake. Furthermore, decreased levels of vaspin early after LRBS seem more likely to result from decreased dietary intake rather than weight-loss-induced insulin sensitivity improvement.</p>