John Libbey Eurotext

European Cytokine Network

Predictive ability of circulating osteoprotegerin as a novel biomarker for early detection of acute kidney injury induced by sepsis Volume 28, issue 2, June 2017

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Authors
1 Misr International University, Faculty of Pharmacy, Department of Biochemistry, Cairo, Egypt
2 Cairo General Hospital, Chemistry Department, Cairo, Egypt
* Correspondence: M. Schaalan. Misr International University, Faculty of Pharmacy, Department of Biochemistry, Km 28, Cairo-Ismailia Road, P.O. Box 1, Heliopolis, Cairo, Egypt
a Both authors contributed equally.
  • Key words: osteoprotegerin, KIM-1, cystatin C, sepsis, acute kidney injury
  • DOI : 10.1684/ecn.2017.0393
  • Page(s) : 52-62
  • Published in: 2017

Background

Though significant progress has been made towards new diagnostic approaches for early detection of acute kidney injury (AKI) induced by different factors, there is still an urgent demand for a more specific and predictive biomarker for each type. The aim of this study is to unravel the potential diagnostic utility of circulating osteoprotegerin (OPG) in septic patients who developed AKI in the ICU, compared to cystatin C (a renal function maker) and KIM-1 (a kidney damage marker).