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 Printable version |
B19 parvovirus and pregnancy |
Virologie. Volume 6, Number 2, 123-31, Mars - Avril 2002, Revues
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 Résumé
Article gratuit
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Author(s) : M. Leruez-Ville |
Summary : Annual B19 seroconversion rates among pregnant women is 2 % during endemic periods and 10 % during epidemic periods. However, the risk of developing nonimmune hydrops after maternal primary infection is low (1 %). Maternal B19 infection may be complicated by spontaneous abortion. A Th1-type reaction with production of the IL2 cytokine in the B19 infected placenta might partially explain these miscarriages. B19 infection has also been associated with late intrauterine death in non-hydropic fetus. Relation between these fetal demises and fetal viral myocarditis should be explored. Fetal infection diagnosis is done by detection of B19 DNA in fetal blood or in amniotic fluid by PCR technology. The non-structural protein gene is the best target for B19 PCR. Intra-uterine transfusions improve the prognosis of B19 fetal hydrops. Congenitally infected children have normal long-term development. |
Keywords : Virus B19 - Fetal infection - Hydrops fetalis - Myocarditis. |
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