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 Printable version |
Various receptor candidates of hepatitis B virus |
Virologie. Volume 4, Number 6, 473-83, Novembre - Décembre 2000, Revues
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 Résumé
Article gratuit
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Author(s) : J.-C. Duclos-Vallée, H. Mabit, S. Ducloux, F. Capel, S. Dubanchet, M.-A. Petit |
Summary : The initial event in the life cycle of a virus is its attachment to specific receptors on host cells, which consitutes a major determinant of virus tropism. Many specific HBV envelope binding proteins have been identified. The pre-S2 and S regions possess a polymerized human serum albumine binding site. Apolipoprotein H and human annexin V (hAV) interact with the HBs domain. A 50-kd metalloproteinase binds to pre-S1 and pre-S2 domains. Various proteins, such as interleukin 6, immunoglobulin A receptor, asialoglycoprotein receptor, glyceraldehyde-3-phosphate dehydrogenase, CD1a and a 80 kd protein which interacts with the pre-S1 domain are described. Furthermore, GAPDH and annexin V determine in vitro cell infectability by HBV. The respective roles of the three protein domains of HBV envelope and of the various receptor candidates is discussed. |
Keywords : Hepatitis B virus – Receptor. |
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