The tissue-specific “ferromagnetic attack” on hyperactivation of ATP synthesis by magnesium-25 in mitochondria

Oleg A. Shatalov; Andrey A. Svistunov; Yuri K. Napolov; Alexander A. Bukhvostov; Dmitry A. Kuznetsov; Renad N. Alyautdin

doi:10.1684/mrh.2012.0328



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The tissue-specific “ferromagnetic attack” on hyperactivation of ATP synthesis by magnesium-25 in mitochondria
Magnesium Research. Volume 25, Number 4, 177-81, December 2012, Short communication
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Author(s) : Oleg A. Shatalov, Andrey A. Svistunov, Yuri K. Napolov, Alexander A. Bukhvostov, Dmitry A. Kuznetsov, Renad N. Alyautdin
Summary : A ²⁵Mg ²⁺-operated hyper -activation of ATP synthesis has been investigated in mitochondria (Mt) isolated from iron-rich and iron-poor rat tissues: spleen, liver, skeletal muscle, myocardium, kidneys, brain. Both magnetic ( ²⁵Mg) and non-magnetic ( ²⁴Mg) magnesium isotopes were separately administered to estimate the degree of the ATP production related to the magnetic isotope effect (MIE) of ²⁵Mg ²⁺as a function of the amount of Mt-endogenous iron ions. A strong but negative ( r \= -0.88) correlation between the ²⁵Mg-MIE degree and the Mt[Fe ²⁺] values was found. The physical and biophysical mechanisms behind these phenomena, as well as the possible impact of these data on further biochemical and pharmacological studies involving ²⁵Mg-promoted nuclear spin selectivity in mitochondrial function, are under discussion.
Keywords : magnesium-25, ferromagnetism, mitochondria, ATP