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 Printable version |
Aging impairs the protective effect of magnesium supplementation on hypertension in spontaneously hypertensive rats |
Magnesium Research. Volume 20, Number 3, 196-9, September 2007, Original article
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 Free Article
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Author(s) : Toshiyuki Sado, Hidekazu Oi, Mariko Sakata, Shozo Yoshida, Ryuji Kawaguchi, Seiji Kanayama, Hiroshi Shigetomi, Shoji Haruta, Yoriko Tsuji, Sachiyo Ueda, Takashi Kitanaka, Yoshihiko Yamada, Hiroshi Kobayashi |
Summary : Preeclampsia is a hypertensive disorder that is unique to pregnancy. Magnesium (Mg
2+) supplementation is a potential new therapy to ameliorate development of hypertension. The aim of this work was to compare the effects of Mg
2+ supplementation on systolic blood pressure (SBP) in young and aged rats. Spontaneously hypertensive rats (SHR) were divided into young (6-week-old male, n \= 10) and old (16-week-old male, n \= 10) groups. Each group of rats comprised two subgroups made of a control subgroup fed with normal rat chow (0.2% Mg
2+, n \= 5) and a high Mg
2+ subgroup nourished with a Mg
2+ rich diet (0.8% Mg
2+, n \= 5). Age-matched Wistar-Kyoto rats (WKY) were also allocated into two groups. SBP was assessed weekly for 12 weeks indirectly by the tail-cuff method. SBP increased progressively in SHR-young rats after 7 weeks. This increase was greater in the control subgroup compared to high Mg
2+ subgroup at 7 weeks (p <\; 0.05). No difference in the SBP was registered between old SHR subgroups. Mg
2+ supplementation does not exert antihypertensive effects in the WKY rats. In conclusion, Mg
2+ supplementation may provide beneficial effect in the developmental phase of hypertension but not in established hypertension. |
Keywords : aging, hypertension, magnesium |
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