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 Printable version |
Onset of nephrocalcinosis depends on dietary phosphorus concentration in male rats fed a magnesium-deficient diet |
Magnesium Research. Volume 19, Number 4, 255-60, December 2006, Original article
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 Free Article
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Author(s) : H Matsuzaki, S Katsumata, M Uehara, M Miwa, K Suzuki |
Summary : Although a magnesium (Mg)-deficient diet is generally known to induce nephrocalcinosis, our previous study observed that despite the administration of a Mg-deficient diet, the kidney calcium (Ca) and phosphorus (P) concentrations were not increased in male rats. We speculated that this result was due to the P concentration of the experimental diet based on the AIN-93G formula used in the previous study. In the present study, male rats were fed modified AIN-93G diets containing the two different Mg concentrations [0.5 g per kg diet (normal-Mg) or Mg-free (Mg-deficient)] and three different P concentrations [3 (3-P), 5 (5-P) or 7 (7-P) g per kg diet]. By histological examination of the kidney, nephrocalcinosis was not observed in rats fed on the Mg-deficient diet containing 3-P. While nephrocalcinosis appeared in rats fed on the Mg-deficient diet containing 5-P and 7-P. The degree of nephrocalcinosis was severe in rats fed on the Mg-deficient diet containing 7-P compared with rats fed on the Mg-deficient diet containing 5-P. These results demonstrated that the Mg-deficient diet based on AIN-93G formula dose not induce nephrocalcinosis and that the Mg-deficient diet based on AIN-93G formula with increased dietary P concentrations induces nephrocalcinosis in male rats. We suggest that the onset of nephrocalcinosis could depend on the dietary P concentration in male rats fed on a Mg-deficient diet. |
Keywords : magnesium-deficient diet, dietary phosphorus, nephrocalcinosis, male rats |
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