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 Printable version |
Magnesium-deficient diet-induced reduction in protein utilization in rats is reversed by dietary magnesium supplementation |
Magnesium Research. Volume 19, Number 1, 19-27, March 2006, Original article
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 Free Article
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Author(s) : Tomoko Nemoto, Hiroshi Matsuzaki, Mariko Uehara, Kazuharu Suzuki |
Summary : We investigated the effect of dietary magnesium (Mg) level on protein utilization in rats. Male Wistar rats were fed a control diet (control group) and a Mg-deficient diet (Mg-deficient group) for 28 days. After 28 days, the diet of half of the Mg-deficient group (recovery group) was changed from the Mg-deficient diet to the control diet for either 7 or 14 days. After 28 days, final body weight, weight gain and food efficiency were significantly decreased due to the Mg-deficient diet. Apparent Mg absorption, Mg retention and serum Mg levels were also significantly decreased due to the Mg-deficient diet. Furthermore, the Mg-deficient group showed a significant increase in urinary nitrogen (N) excretion and significant decreases in N retention and serum albumin level. At day 7 and 14 after changing the Mg-deficient diet to the control diet, apparent Mg absorption, Mg retention and serum Mg levels were significantly increased in the recovery group as compared with those in the Mg-deficient group. However, with regard to final body weight, weight gain and food efficiency, no significant differences were observed between the Mg-deficient group and the recovery group. At day 14 after changing the diet, urinary N excretion was significantly decreased and N retention was significantly increased in the recovery group as compared with the Mg-deficient group. At day 7 and 14 after changing the diet, the serum albumin level was also significantly increased in the recovery group as compared with that in the Mg-deficient group. These results suggest that: 1) the Mg-deficient diet depresses protein utilization\; 2) the Mg-deficient diet-induced impairment of protein utilization is reversed by dietary Mg supplementation\; and 3) the Mg-deficient diet-induced growth retardation is not completely reversed after 14 days of Mg supplementation. |
Keywords : dietary magnesium level, protein utilization, rats |
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