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 Printable version |
Stimulation of choline/Mg
2+ antiport in rat erythrocytes by mefloquine |
Magnesium Research. Volume 19, Number 1, 7-11, March 2006, Original article
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 Free Article
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Author(s) : Hans Ebel, Theodor Günther |
Summary : In non Mg
2+-loaded and non malaria-infected rat erythrocytes, mefloquine (100 μmol·l
-1) stimulated choline/Mg
2+ antiport without affecting the Na
+/Mg
2+ antiport. The stimulation of the choline/Mg
2+ antiport by mefloquine, found in this study, and by trifluoperazine and fluvoxamine, reported previously [Ebel et al. Biochim Biophys Acta 2004\; 1167: 132-40], was associated with CF
3 groups attached to the quinoline or benzene ring. The effect of mefloquine on choline/Mg
2+ antiport in vitro was not related to the antimalarial action of mefloquine in vivo. In rat erythrocytes, the choline/Mg
2+ antiport can be differentiated from the Na
+/Mg
2+ antiport through the use of cinchonine that inhibited the choline/Mg
2+ antiport [Ebel et al. Biochim Biophys Acta 2002\; 1559: 135-44], and mefloquine that stimulated the choline/Mg
2+ antiport, whereby the Na
+/Mg
2+ antiport was not affected by either drug at proper concentrations. The Na
+/Mg
2+ antiport and choline/Mg
2+ antiports behave as different molecular entities. |
Keywords : NPP, new permeation pathway, TCA, trichloroacetic acid |
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