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 Printable version |
Elevated concentrations of TNF‐alpha are related to low serum magnesium levels in obese subjects |
Magnesium Research. Volume 17, Number 3, 189-96, September 2004, ORIGINAL ARTICLE
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 Free Article
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Author(s) : Martha Rodríguez‐Morán, Fernando Guerrero‐Romero |
Summary : The aim of this study was to determine the relationship between serum magnesium and TNF‐alpha levels in obese subjects. A cross‐sectional population based study that included 192 non‐diabetic, non‐hypertensive subjects allocated in three categories of body mass index (BMI) <\; 25\; 25 to <\; 30 kg\\m
2\; and 30 kg\\m
2. Elevation of TNF‐alpha levels was defined by serum levels 3.5 pg\\mL, and low serum magnesium by levels 0.74 mmol\\L. Multivariate odds ratios (OR) adjusted by age, HOMA‐IR index, and glucose tolerance status are presented. Obese subjects exhibited higher serum concentration of TNF‐alpha (p ∓ 0.002) and lower serum magnesium levels (p <\; 0.0001) than lean and overweight subjects. Ninety‐one (47.4%) subjects showed elevated levels of TNF‐alpha, of them 7 (10.9%), 31 (48.4%), and 43 (67.2%) in the groups with BMI <\; 25, 25 to <\; 30, and 30 kg\\m
2, respectively. Multivariate OR between low serum magnesium and TNF‐alpha levels in obese subjects was of 1.8, Cl
95% 1.2‐9.1,
P ∓ 0.001, whereas in the lean and overweight individuals of 1.1, Cl
95% 0.7‐8.7,
P ∓ 0.12, and 1.3, Cl
95% 0.9‐10.8,
P ∓ 0.09, respectively. These data shows that low serum magnesium levels and elevated TNF‐alpha are related in the obese subjects. It will be necessary to conduct more studies in order to add new data on this issue. |
Keywords : magnesium, tumor necrosis factor alpha, obesity, insulin resistance, inflammation. |
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