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 Printable version |
Drug dosage adjustment in renal insufficiency patients |
Journal de Pharmacie Clinique. Volume 30, Number 4, 223-8, Décembre 2011, Dossier
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 Résumé
Texte intégral
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Author(s) : Sarah Zimner-Rapuch, Vincent Launay-Vacher |
Summary : Patients with chronic kidney disease (CKD), dialyzed or not, have renal impairment that can affect the kidney capacity of elimination. Patients with renal insufficiency are not able to eliminate drugs as well as patients with a normal renal function. Moreover, renal insufficiency can affect all of the pharmacokinetic profile of drugs. Therefore, it is crucial to take these parameters into account and to adjust drugs dosage, according to renal insufficiency stage. In this article, we will see all the pharmacokinetics modifications due to renal insufficiency. The different ways to find the information about drug dosage adjustment will be explored. Finally, administration of drugs in patients experimenting dialysis will be developed and explained. |
Keywords : renal insufficiency, drug dosage adjustment, pharmacokinetics, dialysis |
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