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 Printable version |
Malaria prophylaxis and the kidney |
Journal de Pharmacie Clinique. Volume 30, Number 4, 201-6, Décembre 2011, Synthèse
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 Résumé
Article gratuit
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Author(s) : Nicolas Janus, Sabine Amet, Sarah Zimner-Rapuch, Gilbert Deray, Vincent Launay-Vacher |
Summary : Malaria is an endemic and potentially lethal disease transmitted by the protozoan parasite Plasmodium. It is currently endemic in more than a hundred countries, which are visited by a hundred and twenty-five million international travellers every year. For dialysis and renal insufficiency patients it becomes increasingly easier to travel to these countries thanks to the recent advances in renal replacement therapy. All pharmacokinetic steps may change in renal impairment patients. Precisely, the pharmacokinetics of some drugs used as prophylactic agents in malaria is altered in those patients. This may modify the effectiveness and safety of such treatments. Pharmacists should be aware of these pharmacokinetic alterations which require subsequent dosage adjustments. This review provides guidelines on how to use antimalarial drugs in patients with renal impairment, should they be hemodialysed or not. |
Keywords : malaria, chemoprophylaxis, renal impairment, pharmacokinetic, dosage adjustments |
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