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Inflammation augments the development of experimental glomerulonephritis by accelerating proteinuria and enhancing mortality |
European Cytokine Network. Volume 23, Number 1, 12-4, March 2012, Research article
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Author(s) : Eva Pfeifer, Johannes Polz, Daniela N. Männel, Sven Mostböck |
Summary : Proteinuria represents a parameter for a damaged filtration capacity of the kidney. We investigated how inflammation influences the development of experimental, immune complex-mediated glomerulonephritis by monitoring proteinuria. Mice pre-treated with LPS or TNF, one day before induction of glomerulonephritis, excreted high levels of protein in the urine immediately after the induction of glomerulonephritis, in contrast to non-treated mice where proteinuria increased steadily after day 3. Protein levels in the urine of pre-treated mice remained elevated over the 15-day observation time. The severity of proteinuria at later times correlated with the degree of tissue pathology and mortality in individual mice. Pre-treatment with inflammatory agents accelerated the development of proteinuria and induced more severe kidney damage. |
Keywords : kidney, inflammation |
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