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 Printable version |
VEGF-A: a critical regulator of blood vessel growth |
European Cytokine Network. Volume 20, Number 4, 158-63, December 2009, Review article
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 Free Article
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Author(s) : Napoleone Ferrara |
Summary : Angiogenesis is required for a variety of normal and pathological, proliferative processes. Numerous regulators of angiogenesis have been identified and characterized over the last decades. Among these, vascular endothelial growth factor (VEGF)-A appears especially important in normal development and in disease processes. Several VEGF inhibitors have been approved by the FDA for the treatment of tumors or the neovascular form of age-related macular degeneration. This article examines the molecular and biological characteristics of VEGF and also discusses preclinical and clinical studies with VEGF inhibitors and the lessons learned from these studies. |
Keywords : VEGF, VPF, angiogenesis, tumor |
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