European Cytokine Network
MENUThe LIF cytokine: towards adulthood Volume 20, numéro 2, June 2009
Auteurs
Marina Trouillas, Claire Saucourt, Bertrand Guillotin, Xavier Gauthereau, Jean-Luc Taupin, Jean-François Moreau, Hélène Bœuf
Université de Bordeaux, CNRS-UMR-5164-CIRID, 33076 Bordeaux, France
- Mots-clés : AP1, activator-protein 1, BMP, bone morphogenetic protein, CD, cluster of differentiation, c-fos, FBJ murine osteosarcoma viral oncogene homolog, CIMPR, calcium-independent mannose-6 phosphate receptor, c-jun, avian sarcoma virus 17 oncogene homolog, CLC/CLF, cardiotrophin-like cytokine/cardiotrophin-like factor, c-myc, avian myelocytomatosis viral oncogene homolog, CNTF, ciliary neurotrophic factor, CNTFR, CNTF receptor, CREB, cAMP response element-binding, CT1, cardiotrophin-1, Dapp, dual adaptator of phosphotyrosine and PI3K, D-factor, differentiation factor, Eed, embryonic ectoderm development, EGF, epidermal growth factor, Egr, early growth response, ERK, extracellular signal-regulated kinase, ES cells, embryonic stem cells, FGF, fibroblast growth factor, Foxp3, forkhead box protein3, Fra, Fos-related antigen, HDAC, histone deacetylase, Hgf, hepatocyte growth factor, HLA, human leukocyte antigen, Ier, immediate-early response, Igfbp3, insulin growth factor binding protein-3, IL, interleukin, IL-6R, IL-6 receptor, IL-11 R, IL-11 receptor, iPS cells, induced pluripotent stem cells, Irg1, immune response gene-1, JAK, Janus kinase, junB, oncogene JUN-B, KLF, Kruppel-like factor, KO, knock-out, LIF, leukaemia inhibitory factor, Lifind, LIF-induced genes, LIFR, LIF receptor, MW, molecular weight, NANOG, from Tir Na Nog, OCT, octamer-binding transcription factor, OSM, oncostatin M, OSMR, OSM receptor, p53, Tp53, tumor protein 53, PI3 kinase, phosphatidylinositol 3-kinase, RSK, ribosomal S6 kinase, RT-PCR, reverse transcriptase polymerase chain reaction, SHP2, Src homology region 2, phosphatase 2, SOCS, suppressor of cytokine signaling, SOX, SRY-related-HMB-box, STAT, signal transducer and activator of transcription, SWS, Stuve-Wiedemann syndrome, TAM cells, tumor associated macrophages cells, Treg, T regulatory cells, VEGF, vascular endothelial growth factor, Wnt, wingless-type mmtv integration site family, Zfp, zinc finger protein
- DOI : 10.1684/ecn.2009.0148
- Page(s) : 51-62
- Année de parution : 2009
The aim of this article is to recapitulate the key features of leukaemia inhibitory factor cytokine (LIF), to review its numerous physiological effects and to comment on the most recent data. We will also present results of transcriptome analyses, which have highlighted different categories of LIF targets, identified in murine embryonic stem (ES) cells and early derivatives. We hope to stimulate new research fields on this puzzling cytokine, which, forty years after its discovery, has still not disclosed all its secrets.