JLE

European Cytokine Network

MENU

The LIF cytokine: towards adulthood Volume 20, numéro 2, June 2009

Auteurs
Université de Bordeaux, CNRS-UMR-5164-CIRID, 33076 Bordeaux, France

The aim of this article is to recapitulate the key features of leukaemia inhibitory factor cytokine (LIF), to review its numerous physiological effects and to comment on the most recent data. We will also present results of transcriptome analyses, which have highlighted different categories of LIF targets, identified in murine embryonic stem (ES) cells and early derivatives. We hope to stimulate new research fields on this puzzling cytokine, which, forty years after its discovery, has still not disclosed all its secrets.