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 Printable version |
Maternal serum proinflammatory cytokines in preterm labor with intact membranes: neonatal outcome and histological associations |
European Cytokine Network. Volume 18, Number 2, 102-7, June 2007, Research papers
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 Free Article
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Author(s) : Andrzej Torbé, Ryszard Czajka, Agnieszka Kordek, Rafał Rzepka, Sebastian Kwiatkowski, Jacek Rudnicki |
Summary : Our aim was to compare maternal serum concentrations of interleukin(IL)-1α IL-1β, IL-6 and IL-8 in pregnancies complicated by preterm labor (PTL), with the levels in healthy controls at comparable gestational age, and to determine if these assays have any value in the prediction of early-onset neonatal infection or histological chorioamnionitis. The study population consisted of 65 women with new-onset PTL, and 31 healthy controls. Maternal serum concentrations of IL-6 (8.40 versus 3.30 pg/mL\; p \= 0.002) and IL-1β (2.20 versus 0.50 pg/mL\; p \= 0.003) were significantly higher in patients with PTL as compared to healthy pregnant women. The IL-1β concentration (13.60 versus 1.20 pg/mL\; p \= 0.02) was significantly higher in the serum of mothers whose babies developed early-onset infections, than in mothers of newborns that were healthy. However, its predictive value, and the value of the other cytokines studied, was poor. In addition, IL-1β levels (28.79 versus 5.19 pg/mL\; p \= 0.001) were significantly higher in patients with histological chorionamnionitis, than in those without the condition,. The cut-off value of ≥ 14 pg/mL predicted inflammatory changes with a sensitivity of 80%, specificity of 86%, PPV of 80% and NPV of 86%. IL-1β seems to be of moderate value in the prediction of histological chorioamnionitis. |
Keywords : cytokine, histological chorioamnionitis, infection, maternal serum, preterm labor |
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