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 Printable version |
The association of the carrier state of the tumor necrosis factor-α (TNFα)
-308A allele with the duration of oxygen supplementation in preterm neonates |
European Cytokine Network. Volume 16, Number 1, 78-80, March 2005, Research papers
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 Free Article
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Author(s) : Géza Bokodi, András Treszl, László Derzbach, Ádám Balogh, Barna Vásárhelyi |
Summary : Background. High levels of inflammatory cytokines lead to lung damage in premature newborns. We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the length of oxygen supplementation. Methods. We genotyped 123 very low birth weight (VLBW) infants for the tumour necrosis factor (TNF)- α G
-308A, interleukin (IL)-1β C
3954T, IL-6 G
-174C and IL-10 G
-1082A SNPs. Genomic DNA was isolated from remnant dried blood samples from the neonates. We tested the association between SNPs and ventilation characteristics using a stepwise multiple regression analysis model. Results. The carrier state of the TNF-α G
-308A allele was associated with a 40-hour longer period of mechanical ventilation (p\=0.004) and, on average, an additional 36 hours of oxygen supplementation (p\=0.0008). The association was significant after its adjustment for perinatal risk factors for lung damage. Conclusions. The TNF-α G
308A genotype – which is associated with increased TNF-α levels – might influence the supplemental oxygen requirement of VLBW infants. |
Keywords : cytokine, genetic polymorphism, preterm neonate, oxygen supplementation, tumour necrosis factor alpha |
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