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 Printable version |
Cytokines as potential therapeutic targets for inflammatory skin diseases |
European Cytokine Network. Volume 16, Number 2, 101-3, June 2005, Review papers
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 Free Article
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Author(s) : Robert P Numerof, Charles A Dinarello, Khusru Asadullah |
Summary : A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous inflammatory diseases. Thus, the delineation of precise roles for particular cytokines and the development of cytokine-directed therapeutics have become areas of intense investigation. While anti-TNF therapeutics have proven to be effective for the treatment of psoriasis, clinical investigations have now begun with other cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that target cytokines directly, strategies that target cytokine signaling pathways are in development too. In this short review, we summarize key findings from a recent workshop on cytokines as potential therapeutic targets for inflammatory skin diseases. |
Keywords : cytokines, inflammation, psoriasis |
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