European Cytokine Network
MENUNeutrophil a-defensin human neutrophil peptide modulates cytoline production in human monocytes and adhesion molecule expression in endothelial cells. Volume 11, numéro 2, June 2000
Illustrations
Laboratory of Cellular and Molecular Immunology, Institute of Hematology and Blood Transfusion,
Dolginovski Trakt 160, Minsk, 223059, Belarus.
- Page(s) : 257-66
- Année de parution : 2000
INTRODUCTION The production of small (3 to 6 kDa), cationic beta-sheet tridisulphide antimicrobial peptides, so-called defensins [1-4], is an important mechanism of innate immunity in eukaryotes [1-4]. Mammalian defensins, comprising genetically distinct alpha and beta subfamilies [3, 4], and their recently discovered cyclic theta-form [5], appear to be expressed constitutively or are induced by inflammation [4]. alpha-defensins are packaged [...]