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European Cytokine Network

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Pretreatment expression of the perforin gene vy circulating CD8+ T lymphocytes predicts biochemical response to interferon alpha in patients with chronic hepatitis C. Volume 11, numéro 2, June 2000

Auteurs
Hôpital Antoine-Béclère, Service d’hépato-gastro-entérologie, 157, rue de la Porte-de-Trivaux, 92140 Clamart, France.
  • Page(s) : 177-84
  • Année de parution : 2000

INTRODUCTION Treatment of aggressive chronic hepatitis C with interferon-alpha (IFN-alpha) leads, in approximately 30% of patients, to a sustained biochemical response (SBR), defined on the basis of a persistent normalization of alanine aminotransferase (ALT) serum levels 6 months after stopping therapy. A sustained virological response (SVR), defined as the eradication of hepatitis C virus (HCV), is reached in only 15 to 20% of patients [...]