European Cytokine Network
MENUPretreatment expression of the perforin gene vy circulating CD8+ T lymphocytes predicts biochemical response to interferon alpha in patients with chronic hepatitis C. Volume 11, numéro 2, June 2000
Illustrations
A. Balian, S. Naveau, W. Zou, I. Durand-Gasselin, L. Bouchet, A. Foussat, P. Galanaud, J.-C. Chaput, D. Emilie
Hôpital Antoine-Béclère, Service d’hépato-gastro-entérologie, 157, rue de la Porte-de-Trivaux, 92140 Clamart, France.
- Page(s) : 177-84
- Année de parution : 2000
INTRODUCTION Treatment of aggressive chronic hepatitis C with interferon-alpha (IFN-alpha) leads, in approximately 30% of patients, to a sustained biochemical response (SBR), defined on the basis of a persistent normalization of alanine aminotransferase (ALT) serum levels 6 months after stopping therapy. A sustained virological response (SVR), defined as the eradication of hepatitis C virus (HCV), is reached in only 15 to 20% of patients [...]