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European Cytokine Network

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Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet b-cells and up-regulated by interferon-g. Volume 11, numéro 2, June 2000

Auteurs
Steno Diabetes Center, 2 Niels Steensensvej, DK- 2820 Gentofte, Denmark.
  • Page(s) : 193-205
  • Année de parution : 2000

INTRODUCTION Interleukin-18 (IL-18), previously called interferon-gamma (IFN-gamma) inducing factor [1], is a recently identified cytokine [2, 3] which is transcriptionally controlled by both constitutive and inducible promoter activity [4]. Produced by macrophages [2], dendritic cells [5], keratinocytes [6], osteoblasts [7], chondrocytes [8], astrocytes [9], as well as pituitary gland and adrenal cortical cells [10], IL-18 has a wide range [...]