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European Cytokine Network

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Positional cloning of LPS, and the general role of toll-like receptors in the innate immune response. Volume 11, numéro 2, June 2000

Auteurs
The Howard Hughes Medical Institute, 5323 Harry Hines Blvd., Y5.224, Dallas, TX 75235-9050, USA
  • Page(s) : 143-52
  • Année de parution : 2000

INTRODUCTION In the course of evolution, multicellular organisms have developed immune mechanisms that protect them from the predations of unicellular life forms. The most fundamental attribute of any immune system is its ability to distinguish self from non-self. Beyond this, an immune system must be able to recognize a wide diversity of would-be pathogens if it is to be effective. In general, an immune system has a "sensing" (afferent) [...]