JLE

European Cytokine Network

MENU

Distinct patterns of cytokine regulation in discrete clinical forms of Plasmodium falciparum malaria. Volume 11, numéro 1, March 2000

Auteurs
Immunology Unit, Noguchi Memorial Institute for Medical Research, University of Ghana, Box 25, Legon, Ghana. malimmun@ghana.com

INTRODUCTION Although little is known about the pathogenesis of severe P. falciparum malaria in general, the pathogenesis of both cerebral malaria (CM) and severe malarial anaemia (SA) appear to involve dysregulation of the cytokine arm of the immune response to the infection. Thus, CM in general, and fatal CM in particular, are associated with high plasma levels of TNF [1], presumably causing upregulation of endothelial adhesion molecules [...]