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 Printable version |
Interleukin-18: biological properties and clinical implications |
European Cytokine Network. Volume 11, Number 1, 15-26, March 2000, Revue
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 Free Article
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Author(s) : S. Lebel-Binay, A. Berger, F. Zinzindohoué, P.-H. Cugnenc, N. Thiounn, W.H. Fridman, F. Pagès |
Summary : IL-18, originally identified as interferon-gamma inducing factor (IGIF), is related to the IL-1 family in terms of its structure, processing, receptor, signal transduction pathway and pro-inflammatory properties. IL-18 is also functionally related to IL-12, as it induces the production of Th1 cytokines and participates in cell-mediated immune cytotoxicity. This review summarizes the recent advances in the understanding of IL-18 structure, processing, receptor expression and immunoregulatory functions, and focuses on the role of IL-18 modulation in tumours, infections, and autoimmune and inflammatory diseases. |
Keywords : IL-18, IFN-g, Th1 differentiation, inflammation, clinical implications. |
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